Dual immune checkpoint blockade in gastroesophageal tumors: never say never

Never Say Never in Medicine

F or over two decades I have religiously clung to the notion that maternal hyperglycemia is the root of all evil in pregnancies complicated by diabetes (1). To this end, I have valiantly waved the flag for universal screening for gestational diabetes (2), intensified glucose monitoring (3,4), and intensified insulin delivery for all women with hyperglycemia in pregnancy (5). In addition, I cham...

Parenteral nutrition: never say never

This review emphasizes the benefits of parenteral nutrition (PN) in critically ill patients, when prescribed for relevant indications, in adequate quantities, and in due time. Critically ill patients are at risk of energy deficit during their ICU stay, a condition which leads to unfavorable outcomes, due to hypercatabolism secondary to the stress response and the difficulty to optimize feeding....

Never Say Never Probabilistic & Temporal Failure Detectors

The failure detector approach for solving distributed computing problems has been celebrated for its modularity. This approach allows the construction of algorithms using abstract failure detection mechanisms, defined by axiomatic properties, as building blocks. The minimal synchrony assumptions on communication, which enable to implement the failure detection mechanism, are studied separately....

9 things you should never say to a patient.

Let’s face it: Like everyone else, physicians don’t always say the right things. “Do you always weigh that much?” is an example that we heard about, um, somewhere. And when we polled for cringe-worthy comments, a few physicians teased, “Hunh, where’d my watch go?” and “Which leg are we operating on?” But there are less obvious and more insidious phrases that find their way into physician-patien...

Comedy Means Never Having to Say You're Sorry